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( Figure S1 ) Risk of bias was evaluated separately for efficacy and safety outcomes

Head-to-Head Comparison When to Choose MOTS-c Insulin sensitivity is your primary goal You want metabolic improvement, exercise enhancement Insulin sensitivity, exercise capacity, metabolic health are your focus areas When to Choose Tesamorelin Visceral fat reduction is your primary goal You want gh stimulation, visceral fat reduction Visceral fat reduction, body composition, lipodystrophy are your focus areas Can You Use Both

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Do not use the medication after the expiration date, as potency cannot be guaranteed

The samples were homogenized using a motorized pestle on dry ice, followed by the addition of ice-cold 90% methanol for worms or a 1:2 dilution with 100% methanol for the medium