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In a randomized controlled trial of 160 gout patients, the anti-inflammatory effects of probiotic supplementation were associated with BA-mediated inhibition of the activation of the NLRP3 inflammasome and reduced PGE2 expression via butaprost modulation (123)

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The concentration was 50 to 100 times lower than standard GHK-Cu serums (0.02% vs 1 to 2%), which likely explains the modest outcome

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