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HNSCCs originate from the mucosal epithelium in the oral cavity, pharynx and larynx and are most common malignancies that arise in head and neck

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In this regard, a smaller size and a higher surface area of nanomedicines act as a double-edged sword, determining the high reactivity of nanomaterials, which can contribute both to effectiveness and toxicity

Preclinical research models have explored its interactions with angiogenic signaling, tissue response pathways, and receptor-associated biological mechanisms in small-animal and in-vitro studies