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Fifty rats were randomly divided into five groups: Control Group: Received distilled water (1 mL/day) via oral gavage for 30 days

Schafer FQ, Buettner GR Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

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Consider discontinuing acetylcysteine if low risk of hepatotoxicity: paracetamol concentration 75 mg/kg over 1 hour or less All staggered paracetamol overdoses When to treat Management of paracetamol overdose depends on the type of overdose (acute vs staggered), time since ingestion and patient characteristics

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