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This behavior might suggest why in RMSF fluctuation, when FAD binds to the protein, the region 400-420 showed a highest RMSF fluctuation (Fig

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So that, they may compete with some AADs that bind in considerable amount to plasma proteins and/or dependent on tubular secretion, e.g., disopyramide which has a binding affinity to the plasma protein, plasma acid alpha-1-glycoprotein and will be reflected on its renal clearance [80]