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Transcriptomics of wild-type mice and mice lacking ADAMTS-5 activity identifies genes involved in osteoarthritis initiation and cartilage destruction

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Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

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Highlighting the key role testosterone plays as a primary anabolic hormone in muscle adaptation following exercise training, through its interaction with anabolic signaling pathways and other hormones via the androgen receptor (AR), this review also describes the potential importance of fluctuations in other hormones such as GH and IGF-1 in concert with dietary amino acid availability

The cationic amino acid transporter-2 (CAT-2) mediates arginine uptake, which is required for arginase activity and subsequent collagen production, particularly in macrophages [74]