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NNMT's potential role in epigenetic regulation within adipose tissue is a significant research area, with implications for understanding how metabolic states develop

Mark Bernardi

The compound has since been studied in cartilage and osteoarthritis research and remains in active use as a research tool for investigating 3-AR-mediated lipid metabolism

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Other reasons include: bariatric surgery or bowel resection, age, those with GI diseases such as Crohns and Celiac, people taking Metformin to control their blood sugar and thos taking proton pump inhibitors (Prevacid, Prilosec, etc) for chronic heartburn