GLP-1 receptors are expressed in several key regions implicated in addiction and reward processing, including the ventral tegmental area (VTA), nucleus accumbens, amygdala, hippocampus, and lateral hypothalamus
Birth defects occur in 3-4% of pregnancies among women with these conditions versus 2-3% in the general population
When you under-eat or skip meals, your brain enters the Famine Mode, turning the volume knob of food obsession to the maximum to ensure you find energy to stay alive (your body is programmed to help you stay alive!)
Once-weekly glucagon-like peptide-1 receptor agonist dulaglutide is non-inferior to once-daily liraglutide and superior to placebo in Japanese patients with type 2 diabetes: a 26-week randomized phase III study
Further, GLP-1RAs block the adhesion of monocytes to endothelium induced by oxidized LDL via extracellular signal-regulated kinase (ERK) 5-Kruppel-like factor (KLF)2 signaling pathway to prevent endothelial permeability [107, 108]
Cardiovascular data on endpoints like MACE-3 or MACE-4 are presently not available yet, but an early meta-analysis demonstrated at least cardiovascular safety in patients with T2D treated with tirzepatide (78, 79)
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