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Severe calorie restriction in perimenopause can actually make things worse by: Further decreasing metabolic rate (adaptive thermogenesis) Increasing cortisol (chronic stress response) Promoting muscle loss over fat loss Disrupting already-irregular hormone patterns Ive seen women eating 1200 calories and doing intense cardio six days per week, completely exhausted and still gaining weight

-- ConsumerLab.com Tests Lipoic Acid Supplements for Quality, Identifying Top Picks White Plains, New York, December 6, 2016 Alpha-lipoic acid supplements may improve insulin sensitivity and blood sugar control in people with type 2 diabetes, reduce symptoms of diabetic peripheral neuropathy, and enhance weight loss when dieting

Chang L, Hu Y, Fu Y, Zhou T, You J, Du J, et al

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Individual response to DSIP varies significantly

Niacinamide is also widely recognized for its anti-inflammatory properties [141]