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Autoantibodies against alpha B-crystallin, a candidate autoantigen in multiple sclerosis, are part of a normal human immune repertoire

This leads to estrogen dominance (often causing weight gain in the thighs and abdomen, as well as cellulite) and inhibits the bodys ability to properly produce T4 thyroid hormone, leading to poor production of the active thyroid hormone (T3)

Louie, L.J

Reference: PubMed (2022)

Dietary exposure to 2, 2, 4, 4-tetrabromodiphenyl ether (PBDE-47) alters thyroid status and thyroid hormone-regulated gene transcription in the pituitary and brain