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Considering that PSC activation is a key factor in pancreatic fibrosis, we speculated that excess ROS production induced by high glucose may induce PSC activation in vivo

Nonetheless, our observed association between thyroid hormone over-replacement and new-onset AF/Aflutter aligns with a nested casecontrol study of 183,360 patients: compared to low levothyroxine exposure, high and medium exposure was associated with 29% (95% CI 1.231.35) and 8% (95% CI 1.041.11) increased odds of AF, respectively [36]