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In phase 3 trials, lecanemab and donanemab slowed clinical decline in early Alzheimers by roughly a quarter to a third over eighteen months, with a known risk of amyloid-related brain swelling and small bleeds

The main additional side effects come from injection site reactions, which remain mild and transient for most users

Tang S, Yang J, Xiao B, Wang Y, Lei Y, Lai D et al (2024) Aberrant lipid metabolism and complement activation in age-related macular degeneration

This concern remains largely theoretical for sermorelin given its physiological rather than supraphysiological effects, but those with history of cancer should consult healthcare providers

CSCs: cancer stem cells

complaints can include fatigue, weakness, weight loss, loss of appetite, nausea, abdominal pain, jaundice, itching, edema and sometimes mental confusion