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Maintaining GSH levels using therapies that do not deplete the bodys GSH (Sestili and Fimognari, 2020) would be the best choice

Disulfide relays and phosphorylative cascades: partners in redox-mediated signaling pathways

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The bioavailability question has been partially answered by human RCT data: Richie et al

46 In a physiological analysis, there was a 59% decrease in caloric intake to reach gastric fullness, along with decreased gastric emptying time for solids and increased insulin sensitivity

Lixisenatide reduced urinary albumin-to-creatinine ratio (UACR) versus placebo at 108 weeks of follow-up by 10% (p = 0.004)