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Its GIP receptor binding is actually the most potent of the three pathways, with an EC50 of 0.0643 nM compared to 0.775 nM for GLP-1

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They also ease joint pain by reducing inflammation and mechanical stress on joints, offering relief for conditions like osteoarthritis

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Nesfatin-1 enhances glucose-induced insulin secretion by promoting Ca(2+) influx through L-type channels in mouse islet -cells