Although these correlations are now known and consolidated, the exact mechanisms underlying the aetiopathogenesis and linking mechanisms remain unclear and data are heterogeneous
K d is a disassociation constant (pM)
Confocal imaging Tyrosine hydroxylase (TH)-Gal4 driven UAS-GFP lines, labeling the neurons with active dopamine synthesis pathway, were crossed with park 13 flies and progenies were exposed to Sp from 10 days AEL
Recent studies have documented the presence of LBs and -syn deposits in multiple other peripheral locations, including the retina, olfactory epithelium, salivary glands, cardiac sympathetic nerves, adrenal glands, and skin [75, 91, 92]
Thaler, R., Spitzer, S., Karlic, H., Klaushofer, K
The agonist TUG469 ameliorates neurodegeneration and motor impairment both in vitro and in animal models of PD by downregulating the NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome [66]