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8 SUMMIT also demonstrated significant improvements in patient-reported outcomes: at 52 weeks, tirzepatide increased KCCQ-CSS, with a between-group mean difference of 6.9 points, and increased 6-minute walk distance, with a between-group mean difference of 18.3 m
The dose escalation design tested different starting doses (2 mg vs 4 mg) to evaluate tolerability
Findings by Nuesch et al
When HIF-1 is not hydroxylated, and is thus not targeted for degradation by ubiquitylation, it migrates to the nucleus leading to an increase in the transcription of HIF-1 target genes
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