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Changes in Fluid Balance: These medications can affect fluid balance in the body, which may result in drier stools

Each one carries its own range of uncertainty

doi: 10.1001/jama.2015.9676

While some folks might notice changes in their appetite and weight early on, the most significant weight loss usually happens over the first four to five months

For information on the use of GLP-1 RAs for the treatment of weight loss see the Endotext chapter entitled Pharmacologic Treatment of Overweight and Obesity in Adults (283)