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(2020) The effectiveness of hyperbaric oxygen therapy (HBOT) in children with autism spectrum disorders Eight components of the ATEC and CARS scales as well as the CARS total score revealed statistically significant improvements. (2021) Effect of hyperbaric oxygen therapy and Tomatis sound therapy in children with autism spectrum disorder We found that the combination of Tomatis sound therapy with hyperbaric oxygen therapy had a superior effect in improving autism symptoms than each intervention alone. (2022) Hyperbaric Oxygen Therapy Alleviates Social Behavior Dysfunction and Neuroinflammation in a Mouse Model for Autism Spectrum Disorders Our research suggests that HBOT has the potential to improve the clinical outcome of ASD by ameliorating some of the core pathophysiological processes responsible for the development of the disorder. (2023) Therapeutic Impacts of Hyperbaric Oxygen Therapy and Risperidone on Children with Autism: A Clinical Trial 180 children with autism, aged 5-8 years were divided into three equal groups Group 1 received 40 sessions of HBOT within two months Group 2 received risperidone (dose: 0.25 mg per day in children weighing less than 20 kg and 0.5 mg per day in cases weighing more) for six months Group 3 as the control group, received a placebo for six months

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The effect of the endocannabinoid system including anandamide: In the CNS, CB1 receptors are expressed pre-synaptically on both glutamatergic and GABAergic interneurons, and activation of these receptors results in inhibition of synaptic transmission, including glutamate release It slows down the activity which leads to seizures

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Nagel JE, Chopra RK, Chrest FJ, McCoy MT, Schneider EL, Holbrook NJ, et al