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Whats happening: New tissue has matured

Hohnholt MC, Blumrich E-M, Waagepetersen HS, Dringen R (2017) The antidiabetic drug metformin decreases mitochondrial respiration and tricarboxylic acid cycle activity in cultured primary rat astrocytes

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This helps defend against free-radical damage and soothe scalp inflammation

The Pyruvate Dehydrogenase Complex (PDHc) When transported into the inner mitochondrial matrix, pyruvate encounters two principal metabolizing enzymes: pyruvate carboxylase, PC (a gluconeogenic enzyme) and pyruvate dehydrogenase (PDH), the first enzyme of the PDH complex (PDHc)