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Adipose tissue serves as a reservoir for recrudescent Rickettsia prowazekii infection in a mouse model

Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death

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It is important to distinguish between a direct pharmacologic effect of the medication and indirect consequences of the physiologic changes these drugs produce