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Regulatory status : GLP-1 medications are prescription-only medicines licensed by the MHRA following rigorous evaluation of safety and efficacy data

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According to the Summary of Product Characteristics (SmPC) for these medications, headache is classified as very common (affecting more than 1 in 10 people) with weight-management doses of GLP-1 receptor agonists such as Wegovy (semaglutide 2.4 mg) and Saxenda (liraglutide 3 mg)

October 28, 2025

placebo) [95]

It plays a critical role in regulating glucose metabolism and appetite