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The mitochondria in the immune cells become swollen, their internal structures (cristae) break down, and they lose the ability to produce adequate ATP

Tretinoin is the active form (all-trans retinoic acid) that binds retinoic acid receptors directly

Heart rate is also phenotype-coupled: near zero at 1 mg in the obese trial cohort, but +10 bpm or more at the same 1 mg in a leaner body from Phase 1b

Hansen MS, Se K, Christensen LL, et al