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GLP-1RAs promote healthy vascular function by targeting the AMP-activated protein kinase (AMPK)/Sirtuin 1 (SIRT1)/FoxO3a pathway, maintaining a calponin+SM22+ vascular smooth muscle cell phenotype [27]

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It means they mimic the gut hormone GLP-1 to help regulate appetite, improve blood sugar, and slow digestion

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Dose Distributions Over the Follow-up Period Figure 3 shows dose distributions of dulaglutide and s.c

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