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Ethics statement The studies involving humans were approved by the local ethics committee of Iran University of Medical Sciences approved the research protocol in accordance with the ethical code IR.IUMS.FMD.REC.1401.570

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Ipamorelin + Tesamorelin is sold strictly for laboratory and research purposes and is not approved by the FDA or other regulators for human use

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Therefore, it is necessary to develop modified versions of GLP-1 or to synthesize GLP-1R agonists to achieve better bioavailability and clinical efficacy in the treatment of patients with T2D