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Front Cell Dev Biol 10:888873

The primary endpoint was change in bodyweight from baseline at 24 weeks, with 48 weeks included as a secondary outcome

For example, taking very high doses of vitamin B6 can lead to potentially irreversible nerve damage over time, while taking large amounts of niacin typically in excess of 2 grams per day can cause liver damage ( Fat-soluble vitamins Unlike water-soluble vitamins, fat-soluble vitamins do not dissolve in water and are easily stored in your bodys tissues ( There are four fat-soluble vitamins: Vitamin A Vitamin D Vitamin E Vitamin K Given that fat-soluble vitamins can accumulate in the body, these nutrients are more likely to lead to toxicity than water-soluble vitamins

However, these structural features should be interpreted as biochemical clues rather than complete explanations of biological activity

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