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Although the clinical and biological characteristics of asthma are heterogeneous, previous cluster analysis of a large cohort of asthmatic patients identified various features of asthma with obesity, including late onset asthma, preponderance in females, greater severity of symptoms, low sputum eosinophil counts, less atopy, moderate AHR and reversibility of airway obstruction, and low responsiveness to inhaled corticosteroids (68)

- Exhibits anti-inflammatory properties

Furthermore, ligands derived from the hexapeptide Ang IV but that are not proven to act as IRAP inhibitors have been reported

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They arent without side effects

The NAD+ precursor nicotinamide riboside rescues mitochondrial defects and neuronal loss in iPSC and fly models of Parkinsons disease