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This peptide starts GLP-1 receptors in multiple tissues including the brain (reducing appetite and food cravings), pancreas (enhancing insulin secretion and suppressing glucagon), and stomach (slowing gastric emptying to prolong satiety)

Moreover, therapeutic strategies aimed at reducing oxidative stress may contribute to disease management by lowering 8-OHdG levels [162, 163]

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Furthermore, a large randomized controlled trial (RCT) on the renoprotective effect of finerenone in DKD is currently ongoing (FIDELIO-DKD)

A phase 2, placebo-controlled, randomized, double-blind trial of tozadenant (Syn-115) in patients with Parkinsons disease with wearing-off fluctuations on levodopa