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Bandeira SDM, Da Fonseca LJS, Guedes GDS, Rabelo LA, Goulart MO, Vasconcelos SML
Improves athletic performance Intense muscle activity leads to an increase in oxidative molecules, such as reactive oxygen and nitrogen species
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Why is it important
Concrete examples of biased agonism that have clearly improved therapeutic outcomes include the development of -arrestinbiased angiotensin II receptor ligands (which showed reduced hypertension-related adverse effects in preclinical models) and carfentanil-class opioid analogs designed to preferentially engage G-protein over arrestin pathways, thereby reducing respiratory depression (Schmid et al., 2017)
This agrees with our results, where asparagine was significantly reduced while aspartic acid increased
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