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It is the leading cause of irreversible blindness globally, with projections indicating it could affect over 100 million individuals by 2040 (74)

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Baseline hemoglobin A1C was approximately 5.7% in STEP 1 and STEP 3, 5.5% in STEP 8, and 5.4% in STEP 4, which featured the run-in, and much higher in STEP 2 (8.1%), which enrolled patients with type 2 diabetes

Accuracy in predicting repetitions to task failure: scoping review

For type 2 diabetes, NICE guidance (NG28) recommends GLP-1 RAs in specific circumstances

Put the three together and the pitch is a loop: supply NAD+, protect NAD+, then flip on the pathways that spend it productively