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GLP-1 plays a crucial role in glucose homeostasis by stimulating insulin secretion in a glucose-dependent manner, suppressing glucagon release, slowing gastric emptying, and promoting satiety

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Trauma, sepsis and wound healing The metabolic process in trauma and sepsis includes greatly accelerated proteolysis and resulting protein loss in skeletal muscle [94]

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Because GLP-1 agonists slow down the digestive tract, they can potentially worsen constipation