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Saltiel, A

By contrast, long-acting GLP-1RAs lower fasting blood glucose and hemoglobin A1c (HbA1c) by stimulating insulin secretion [35]

Laskowski, R., MacArthur, M

Ongoing research into nutritional and exercise interventions, as well as novel pharmacological agents such as myostatin/activin pathway inhibitors (243) or agents targeting the apelin pathway (244) holds promise for preserving lean mass and improving overall health in patients undergoing treatment with GLP-1 and dual GIP/GLP-1 receptor agonists

3.3 Development of unimolecular agents targeting both GIPR and GLP-1R The anti-obesity effects of GIPR antagonism antibody, both alone and in combination with GLP-1RAs, have been demonstrated in preclinical models of mice and monkeys (68, 73)

Portion control becomes particularly important as natural satiety signals change