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The article explains that these medications act on the hypothalamus and brainstem, neural centers that also modulate reproductive hormone signaling, and that rapid weight loss suppresses leptin, an adipokine that helps stabilize estrogen and progesterone cycling

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Most patients only see meaningful weight loss results once they reach the 1.8mg or 3.0mg dose tier

an Internet Survey of Gynecologists' Views

Stopping can worsen glucose control