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Finally, depression is linked to disruptions in the brains reward circuitry which is what leads to anhedonia, one of the key symptoms of depression

In the hours to days following the initial injury, neuronal and glial dysfunction, metabolic changes, neuroinflammation, and the release of signaling and inflammatory molecules from neurons, glial cells, and immune cells occur

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The degradation of mitochondria, which serve as copper pools, may release increased levels of copper, similar to the release of iron during ferroptosis