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Individuals with this disorder experience megaloblastic anemia, mental retardation, convulsions, and movement disorders

However, whether metformin prevents MG-induced beta cell apoptosis is controversial

At the 24-week mark in clinical trials, mean body weight reduction ranged from 7.2% at 1mg to 17.5% at 12mg, compared to 1.6% with placebo

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As a result, the ETC functioning is disrupted, and ATP content becomes significantly depleted, which breaks down metabolic and ionic homeostasis and activates the degradative enzymes such as nucleases, proteases, and phospholipases [182, 188]

Canagliflozin mitigates ferroptosis and ameliorates heart failure in rats with preserved ejection fraction