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10.1016/j.cellsig.2024.111531 135 ZhaoM.WangY.LiL.LiuS.WangC.YuanY.et al (2021)

Protective action of the peroxisome proliferator-activated receptor- agonist pioglitazone in a mouse model of Parkinson's disease

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1 Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a standard class of medications that are used to treat type 2 diabetes mellitus (T2DM) (Collins and Costello, 2024) These medications mimic the actions of a hormone naturally found in the intestines, glucagon-like peptide-1 (GLP-1), which regulates blood sugar levels by increasing insulin secretion and decreasing glucagon release

This means its efficacy is directly related to its systemic concentration and availability [5]