CMAJ 2 AkaikeA.Takada-TakatoriY.KumeT.IzumiY
Point mutations and NNK site saturation libraries of PtGSTF8 were constructed by overlap extension PCR as previously reported 49 using primers T7 fw, T7 term and: PtGSTF8 (V12X): V12C13_rv and V12X_fw, PtGSTF8 (C13X): V12C13_rv and C13X_fw, PtGSTF8 (C13S): V12C13_rv and C13S_fw, PtGSTF8 (N108X): N108_rv, N108X_fw, PtGSTF8 (F112X): F112_rv, F112X_fw (Supplementary Table 4) using pANT35 as template
Finally, all animals showed identical levels of neuronal and BBB integrity to corroborate the striking absence of other putative drivers of the non-spatial memory deficit and elevated glial burden we observed
The GO@GSH-FA treated group showed no signs of pulmonary toxicity
Food and Drug Administration (FDA) for weight loss in late 2025
They are most suitable when targeting small areas with a lower volume of fat, providing gradual contouring without the need for surgery