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Before starting: Baseline labs such as A1C, kidney function, and liver function tests to confirm you can take the medication safely During treatment: Follow-up labs at 36 months, or sooner if you have preexisting conditions or unusual symptoms Ongoing review: Regular check-ins to track weight, blood sugar, and any side effects Dose adjustments: Titration based on tolerance and results, never jumping too quickly to the maximum dose Consistent monitoring is not just a formality

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Consequently, glucocorticoids are at the same time rhythm drivers for these respective clock genes, thus affecting tissue clock regulation (and downstream functions), i.e., they act as zeitgebers

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