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This creates a complex regulatory system of eating behavior, appetite, and weight gain
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J Diabetes 7:584588 [DOI] [PubMed] [Google Scholar] 67.Wen B, Zhao L, Zhao H, Wang X (2018) Liraglutide exerts a bone-protective effect in ovariectomized rats with streptozotocin-induced diabetes by inhibiting osteoclastogenesis
The peptide sequence (SEQ ID NO:1) has a structure of: 7 -Aib 8 -Glu 9 -Gly 10 -Thr 11 -Phe 12 -Thr 13 -Ser 14 -Asp 15 -Val 16 -Ser 17 -Ser 18 -Ty r 19 -Leu 20 -Glu 21 -Gly 22 -Gln 23 -Ala 24 -Ala 28 -Lys 16 (PEG-PEG--Glu- Octadeca -nedioic Acid)-Glu 27 -Phe 28 -Ile 29 -Ala 30 -Trp 31 -Leu 32 -Val 33 -Arg 34 -Gly 35 -Arg 36 -Gly 37 -OH In the prior art (e.g.CN 103848910-A,WO 2014/202727, orCN 104356224-A), a method for synthetizing Semaglutide by sequential coupling using Fmoc solid-phase synthesis to obtain the target polypeptide molecule is provided
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