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Four of the six genes investigated by quantitative RT-PCR were significantly up-regulated by Exendin-4 pre-conditioning, including Lactate dehydrogenase A ( Ldha ), Aldolase A ( Aldoa ), Phosphofructokinase ( Pfkp ) and Glucose-6-phosphate isomerase ( Gpi ) (Fig

The authors write that Louwagies case report (and others) should not detract from the substantial value of GLP-1 based therapies, but they do speak yet again to the importance of individualized therapy

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