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Data sources and search strategy The Cochrane Central Register of Controlled Trials (CENTRAL), PubMed (MEDLINE), Web of Science, SCOPUS databases were all searched until March 2025
Syed, Y
In human studies, the evidence is mixed
"Crucially, it is a tablet taken under prescription - there are no authorised 'oral solutions' of Semaglutide or Tirzepatide anywhere in the world."Other oral GLP-1 drugs, like Orforglipron, are in clinical trials but not yet available
Exclusivity on the peptides has proven robust because the claim protects the key peptide and, even though the generic scope may be limited, there is little structural room for a successful follow-on outside the claim