A substantial body of work establishes that the nuclear hormone receptor, NHR-49, is essential for activating and repressing the expression of genes involved in -oxidation during starvation and plays a critical role in animal physiology and lifespan determination 16
There were 78 subjects randomized to receive the diabetes drug Lixisenatide and 78 randomized to a placebo
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Statements Data availability statement The original contributions presented in the study are included in the article/Supplementary material, further inquiries can be directed to the corresponding author