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Additionally, Wegovy commonly causes gastrointestinal side effects such as nausea, vomiting, diarrhoea, and constipation, which affect a substantial proportion of users according to the SmPC

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The mechanistic rationale is legitimate GHRH analogues and ghrelin-receptor secretagogues act on different receptors, and a GHS cannot release GH at all without intact GHRH signalling but mechanism is a hypothesis, not a dose

The study design seems adequate for Phase 1 objectives related to safety, but additional criteria and primary endpoints are necessary for later phases aimed at providing PoC for efficacy

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176(3): 161723 Cederblad G, Harper P, Lindgren K