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Catalytic mechanism and role of hydroxyl residues in the active site of theta class glutathione S-transferases

2009;297(2):E289

The agency has greater authority over prescription drugs, and it has already slapped medications containing acetaminophen with a black box warning that says overdosing can lead to liver transplant and death. Paradoxically, the same medicine sold over the counter does not tell patients that death is a possible side effect

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Cryogenic electron microscopy data indicate that at least for the echovirus serotype 6m, polar interactions between the 2 domain of FcRn and proteins in the viral coat may enable a viral association with the receptor at the cell surface and trigger endocytosis and a pH-dependent destabilization of the viral particle