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However, clinical trials on GLP-1RAs usually do not last for more than a year ..." Kidney, Cancer Risks Are Also Concerning The long-term risks of semaglutide are unknown, but already the drug carries a black box warning because rodent studies found semaglutide causes thyroid C-cell tumors "at clinically relevant exposures." 26 Pancreatic cancer is another concern

Semaglutide is a long-term medication that should be taken according to your doctors instructions

ROS and pro-inflammatory cytokines further weaken neural network function by affecting synaptic plasticity and neurotransmitter release

Finally I address the issue of long-term weight maintenance and the role of exercise

Choose Light Movement Over Intense Workouts