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In addition, the activity of phosphatase (GPP) domain of Cr GPDH was monitored by a discontinuous assay when inorganic phosphate (Pi) release was monitored by the malachite green (MG) assay

Under physiological conditions, ROS are generated in the heart mainly from the mitochondrial electron transport chain, nitric oxide synthases (NOS), NADPH oxidases (NOX), and xanthine oxidase (XO) in small quantities [7, 8]

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The Phase 2 studies also set up the best titration schedule to minimize gut side effects while keeping effect

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