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Glutathione is a sulfur-containing molecule that can absorb the impact of many of these free radicals

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This research was supported by funding from Diabetes UK (18/0005884 to JR, RD Lawrence Fellowship 21/0006280 to GM), the Biotechnology and Biological Sciences Research Council (BB/V015869/1 to JJR, BB/R01857X/1 and BB/V016849/1 to LH), the Wellcome Trust Institutional Strategic Support Fund to the University of Aberdeen (to LH and JR)

74 While numerous studies demonstrate that elevating sirtuin protein content, such as that of sirtuin 3, ameliorates diabetes and its complications, 67,7577 a question arising is that whether it is possible that elevated levels of sirtuins consume more NAD + and make the redox imbalance situation worse