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Genetic variants in the GLP1R gene (rs6923761) and GIPR gene (rs1800437) influence receptor sensitivity and baseline signaling tone

These findings strongly suggest that alternate metabolic pathways support survival and viability when lipid catabolism is impaired

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The second receptor target is GIP (glucose-dependent insulinotropic polypeptide), which works synergistically with GLP-1 to enhance insulin sensitivity and further regulate appetite

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