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However, the specific inflammatory profiles and cytokine levels may vary between the TMJ and the knee, leading to distinct outcomes in terms of ferroptosis-mediated chondrocyte death and cartilage damage

Although IGF-IR promotes EMT, it does not necessarily mean that inhibition of IGF-IR is able to reverse this phenotype, due to the compensation by other RTKs

274 Prion diseases are caused by accumulation of a pathological prion, known as Prion PrP Sc , which are misfolded polypepetides converted form physiologically significant cell-surface glycoprotein PrP C encoded by the PRNP gene

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Shah et al., 2018)

Embo Journal