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Subcutaneous injection bypasses this degradation and reaches nearly 100 percent bioavailability

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10.1016/j.cmet.2020.04.015 10 BianD.WuY.SongG.AziziR.ZamaniA

Methods: We conducted a population-based cohort study using Danish national health registries

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Briefly, an aliquot of cell homogenate was incubated with the labeled substrate DEVD-pNA (acetyl-Asp-Glu-Val-Asp p-nitroaniline), which is cleaved by the caspase-3 enzyme and releases the chromophore pNA