While some physicians prescribed it off-label for weight loss, the doses used for diabetes (up to 14 mg) were often lower than what is required for maximum weight reduction
The study, which evaluated data from more than 100,000 diabetes patients, found that those taking GLP-1s were upwards of 68 times more likely to develop NAION than those using other treatment methods
People using these medications often say they feel free from constant cravings and find it much easier to stick to healthier eating habits. GLP-1 medications have other health benefits, too
Circulation 142(17):e265e286 American Diabetes Association Professional Practice Committee (2024) 10
This combination ensures that as you lose weight with GLP-1 therapy, your skin adapts and tightens for a smoother, more contoured appearance
The lag is especially acute for peptides: for instance, the Wegovy pill approved in late 2025 is made end-to-end in North Carolina ( [16] ), but its supply depends on scaling semaglutide API production first